Aaron Connolly and Callum Robinson have been ruled out of the Republic of Ireland squad for the games against England, Wales and Bulgaria.
The Brighton and Hove Albion forward will miss the three matches through an injury sustained in training yesterday and Preston North End striker Sean Maguire has been called up as a replacement.
Robinson has been confirmed as the Covid-19 positive case in the Ireland camp and the West Brom forward will also miss all three games.
Swansea City's Ryan Manning has been called up and will link up with the squad ahead of the Wales match on Sunday.
Republic of Ireland Squad
Goalkeepers: Darren Randolph (West Ham United), Caoimhín Kelleher (Liverpool), Mark Travers (AFC Bournemouth).
Defenders: Seamus Coleman (Everton), Matt Doherty (Tottenham Hotspur), Kevin Long (Burnley), Shane Duffy (Celtic, on loan from Brighton and Hove Albion), John Egan (Sheffield United), Dara O'Shea (West Bromwich Albion), Cyrus Christie (Nottingham Forest).
Midfielders: Conor Hourihane (Aston Villa), James McCarthy (Crystal Palace), Harry Arter (Nottingham Forest), Jeff Hendrick (Newcastle United), Alan Browne (Preston North End), Jayson Molumby (Brighton and Hove Albion), Robbie Brady (Burnley), Jack Byrne (Shamrock Rovers), Ryan Manning (Swansea City).
Forwards: Sean Maguire (Preston North End), Callum O'Dowda (Bristol City), James McClean (Stoke City), Adam Idah (Norwich City), James Collins (Luton Town), Ronan Curtis (Portsmouth), Daryl Horgan (Wycombe Wanderers).
