Bono, Joe Strummer and Dave Stewart have written a song in tribute to Nelson Mandela.
They will perform the song, called 48864 after Mandela's prison number, at the end of the Mandela SOS concert on Robben Island on February 2.
The song, based around Strummer's lyrics, ends with the musicians chanting 48864.
The day long concert is being staged to raise international awareness about the AIDS epidemic that has ravaged Africa.
Other musicians scheduled to perform include Queen, Macy Gray, Nelly Furtado, Shaggy, Jimmy Cliff, Johnny Clegg and Youssou N'dour.
"We can think of no better time, place or cause for us to return to the stage," Roger Taylor of Queen, who lost singer Freddie Mercury to AIDS in 1991, told Rolling Stone.
Yusuf Islam, the pop singer who was known as Cat Stevens until he converted to Islam in the late 1970s, will make his first public appearance in three decades at the concert.
Michael Jackson, Sting, Bruce Springsteen, Bob Dylan, Elton John and Janet Jackson have also been approached to play at the event.