Uruguay boss Oscar Tabarez has included Atletico Madrid striker Diego Forlan and skipper Diego Lugano, of Fenerbahce, in his starting line-up for tonight's clash with the Republic of Ireland at the Aviva Stadium.
Meanwhile, James McCarthy has been handed his first senior international start as the hosts welcome the World Cup semi-finalists to Dublin.
The 20-year-old Wigan midfielder, who made his competitive debut as a substitute in last Saturday evening’s 2-1 Euro 2012 victory over Macedonia, lines up behind lone striker Shane Long as manager Giovanni Trapattoni makes eight changes to his team.
Aston Villa defender Ciaran Clark gets a run at left-back, while Fulham’s Stephen Kelly wears the captain’s armband.
Rep of Ireland: Westwood, Foley, O’Dea, Kelly, Clark, Lawrence, Green, Fahey, Keogh, McCarthy, Long.
Subs: Randolph, Treacy, McGeady, Gibson, Delaney, Stokes, Forde.
Uruguay: Muslera, Lugano, Godin, Caceres, Maxi Pereira, Arevalo Rios, Perez, Pereira, Hernandez, Forlan, Cavani.
Subs: Castillo, Fucile, Gargano, Eguren, Abreu, Gonzalez Luengo, Ramirez, Scotti, Fernandez.
Referee: Said Ennjimi (France).