Birmingham midfielder Lee Boywer has recovered from illness and should be available for the home Premier League clash with Everton on Saturday.
Bowyer was ruled out of the mid-week win at Portsmouth when Blues boss Alex McLeish decided to rest several regular players.
Sebastian Larsson, James McFadden and skipper Stephen Carr will be in contention for a return to the starting line-up.
Veteran striker Kevin Phillips is battling to shake off a hamstring niggle.
But right-back Stuart Parnaby, who deputised for Carr at Fratton Park, is ruled out with an ankle injury in the latest of a series of setbacks this season.
Birmingham (provisional squad): Hart, Carr, Johnson, Dann, Ridgewell, Gardner, Larsson, Michel, Bowyer, Ferguson, Fahey, Jerome, McFadden, Benitez, Taylor, Tainio, Murphy, Queudrue, Phillips, Jervis.