Goalkeeper Mark Schwarzer returned for Middlesbrough after two matches out with a shoulder injury.
It was tough luck on stand-in Brad Jones, who gave a superb display in the 0-0 draw against AZ Alkmaar in the UEFA Cup on Thursday.
Manager Steve McClaren made five other changes to the side with Frank Queudrue, Fabio Rochemback, Aiyegbeni Yakubu, Gareth Southgate and Stuart Parnaby all recalled.
West Brom went into the match in buoyant mood after a 4-0 victory against Everton.
Kanu was preferred to Geoff Horsfield in attack while Paul Robinson returned following a three-match suspension. He replaced Martin Albrechtsen.