Andy Farrell's side will then be away to England at Twickenham on November 21st, before returning to the Aviva to welcome Georgia on November 29th.
The fixtures were released earlier today, confirming that the finals weekend will be held on December 5th and 6th.
Teams from Ireland's group A will face off against their corresponding ranked team from group B on the final weekend, with Ireland's last fixture scheduled to take place in Dublin.
The tournament was set up by Six Nations Rugby in response to the autumn tours being abandoned because of the Covid-19 pandemic.
Georgia have replaced Japan in the competition that follows completion of the postponed 2020 Six Nations fixtures after they were forced to withdraw because of logistical complications arising from Covid-19.
A broadcast deal has yet to be agreed but the PA news agency understands that Amazon are front runners to secure the rights.
Six Nations chief executive Ben Morel said: “We are absolutely delighted to formally announce details of the Autumn Nations Cup.
"We cannot wait for the tournament to get underway in November and fans can look forward to some outstanding matches featuring some of the greatest players in the world.
“A significant amount of time and effort has gone into delivering this new tournament format in testing circumstances and the spirit of collaboration amongst key stakeholders has been outstanding.
“While the challenges presented by the Covid-19 pandemic made the traditional Autumn Test window unfeasible, we remained determined to deliver a unique and compelling tournament proposition which would ensure world class rugby for our fans globally, and competitive matches for players, unions and federations.
“We cannot wait for the tournament to get underway in November and fans can look forward to some outstanding matches featuring some of the greatest players in the world.
“We are especially pleased to be joined by Fiji and Georgia and expect them both to be tremendous additions to the competition.”