The ISEQ ended the day down 15.49 points to finish at 6,157.28 as traders began to wind down for the Christmas holidays.
Elan was the main casualty of the day with trading seeing their stock fall 19c to €19.00.
The pharmaceutical giant was closely followed by Food group Kerry (down 15c to €17.75) and construction firm Kingspan (down 15c to €7.00).
Paddy Power and Jurys Hotel group both saw their share price fall 10c to €10.80 and 12.22 respectively, while building materials group CRH fell 8c to €19.75.
Among the financial stocks Allied Irish Bank shares fell 2c to €15.06. Bank of Ireland shares climbed one cent to €12.05 while Anglo Irish Bank shares rose six cent to €17.98.
Shares in Irish Life & Permanent slipped five cent to €13.60. The company today announced the sale of its subsidiary company, Irish Estates Management Ltd (Irish Estates) to a group of private and institutional investors led by Niall McFadden.
Meanwhile, business services support group DCC continued its resurgence today, climbing seven cent to €16.32 and construction firm McInerney Holdings climbed 10c to €6.44.
Television group UTV today agreed to buy a Co Louth radio station for €9.5m. LMFM is based in Drogheda. UTV shares were unchanged today at €6.33.
The most traded shares today are Bank of Ireland, Anglo Irish Bank, AIB, Fyffes and DCC.