Liverpool, Portsmouth and Fulham will compete in the Barclays Asia Trophy in Hong Kong in July.
The four-team tournament line-up will be completed by the winners of Hong Kong's FA Cup at the 40,000-capacity Hong Kong Stadium.
Pompey will take on Fulham in the first semi-final on July 24, with Liverpool facing the Hong Kong entrants later that day.
The third-place play-off and final will then be played on July 27, with all matches to be screened live by Sky Sports.
Premier League chief executive Richard Scudamore said: "The Barclays Premiership has a fantastic following across east Asia, and nowhere more so than in Hong Kong.
"This is a great opportunity for those fans who follow our competition week in week out to experience what a Barclays Premiership game is like in the flesh.
"We have three fantastic clubs who will be putting out strong teams and aiming to win this increasingly prestigious trophy, and I am sure the winners of the Hong Kong FA Cup will be determined to compete."