A woman in her 60s died following a crash on the Bandon to Carhoon road.
She was the passenger in a car which collided with a truck near Baxters Bridge at around 12.40pm.
The driver of the car, a man in his 60s, is in a serious condition at Cork University Hospital.
The road has been closed and local diversions are in place – gardaí are appealing for witnesses to come forward.
Meanwhile, emergency services are dealing with a second fatal road traffic incident in Co Cork.
A man in his 30s was killed after his motorbike was involved in a collision with a van near Dromahane, close to Mallow.
The road has been closed to allow a technical examination by forensic road traffic accident investigators.