Neil Doak has made two changes to the side that were narrowly defeated by Scarlets in the Champions Cup last weekend.
The first change sees Michael Allen start on the left wing. He replaces Craig Gilroy who is rested for this match.
Luke Marshall and Darren Cave continue their partnership in the centre.
Andrew Warwick signed his first senior contract with the province earlier this week and is rewarded with a start at loosehead prop. As a result Callum Black, who started last week, is on the bench for this match.
Also on the bench is Ireland international Stuart Olding, returning from injury.
The match is in the Liberty Stadium on Saturday December 20 - kick-off 5.15pm.
: L Ludik; T Bowe, D Cave, L Marshall, M Allen, I Humphreys, R Pienaar; A Warwick, R Best (Capt), D Fitzpatrick, D Tuohy, F vd Merwe, R Diack, C Ross, R Wilson;
: R Herring, C Black, B Ross, A O’Connor, S Reidy, P Marshall, S Olding, P Nelson.