However, the nine-year-old mare knocked herself when walking in the sea near Motherway’s County Cork yard last week and the injury has not settled down in time for her to take her chance.

“Unfortunately last Thursday morning she was having a little bit of exercise on the beach nearby and she just took a false step in the water and knocked into her front joint,” said Motherway.

“It’s not going to rectify itself in time for the weekend. I’ve just had a consultation with my vet who checked it again and he’s not happy with it so we’ve had to draw a line through it unfortunately.

“If the race had been run on its correct date (December 27) she’d have been there, but there’s nothing you can do about it.

“It’s unfortunate and the owners and myself are all disappointed, but that’s racing. It’s nothing serious but it’s enough to put us out of Saturday’s race.

“She loves it soft so it looked the ideal race for her. I’ve nothing concrete in the pipeline and I’ll just see how this joint settles down over the next week or two.”

Lucinda Russell’s grey Silver By Nature will have to carry top weight following his victory in a valuable event at Haydock last season.

Last year’s winner Dream Alliance is next in the list for Philip Hobbs, but he has been pulled up in his last three races.

Tony McCoy’s expected mount, ante-post favourite Synchronised, will aim to give the perennial champion jockey his first win in the race.

The Welsh National is the only one of the four ’Nationals’ McCoy has yet to win.

He famously landed the Aintree version at the 15th attempt on Don’t Push It, won the Scottish version on Belmont King in 1997 while Butler’s Cabin won the Irish National 10 years later.

Paul Nicholls’ novice Watamu Bay is another high up in the weights, while teenagers Eric’s Charm, Hello Bud and Knowhere are still engaged.

Exmoor Ranger, Summery Justice and Maktu are others to note.

Noel Meade has withdrawn Pandorama, but Irish compatriot Willie Mullins could still be represented by Arbor Supreme.

Following Bluesea Cracker’s withdrawal, McCoy’s mount is now the 11-2 market leader.

“We are delighted that most of the principals look like taking their chance in the rearranged Coral Welsh National, the 38th running of the race under our sponsorship, and hopefully the weather will not prevent AP McCoy from attempting to complete his set of National wins on Saturday,” said Coral’s David Stevens.

Coral Welsh National – sponsors bet:

11-2 Synchronised, 8-1 Maktu, 12-1 Dance Island, Dream Alliance, Watamu Bay, Summery Justice, 14-1 Silver By Nature, 16-1 Exmoor Ranger, Hello Bud, Master Overseer, 20-1 Arbor Supreme, I’moncloudnine, 25-1 Giles Cross, 33-1 Bar