Munster loose-head prop Marcus Horan has not recovered in time from a groin injury for the Heineken Cup semi-final with Leinster at Lansdowne Road on Sunday.
Frederico Pucciariello will step into the breach as he did for last week's Celtic League win over Edinburgh.
Coach Declan kidney has decided to go with the experience of John Kelly at outside centre and Anthony Horgan on the wing to the exlcusion of Tomas O'Leary in the only other difficult decision.
MUNSTER (v Leinster): S Payne; A Horgan, J Kelly, T Halstead, I Dowling; R O'Gara, P Stringer; F Pucciariello, J Flannery, J Hayes, D O'Callaghan, P O'Connell, D Leamy, D Wallace, A Foley (capt).
Replacements: D Fogarty, F Roche, M O'Driscoll, S Keogh, J Manning, R Henderson, T O'Leary