England have suffered a setback on the eve of their Autumn Nations Cup final against France after Mako Vunipola was ruled out by a calf problem.
Vunipola sustained the injury against Wales last Saturday and has been unable to recover in time for Sunday’s Twickenham showdown.
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Ellis Genge is promoted from the bench into the starting XV, with Joe Marler filling the vacancy among the replacements.
Attack coach Simon Amor said: “Mako picked up an injury in last week’s game. We’ve given him every opportunity to recover for this one but unfortunately he hasn’t made it.”
