The old rivals meet at Tallaght Stadium in a 2pm kick-off on Saturday.
Rovers are unbeaten in the League of Ireland Premier Dvision this season while Bohemians have won their last five league games. Rovers are currently two points ahead at the top of the table but a victory for Bohemians would see them leapfrog their rivals so there's a lot on the line.
The clubs had contrasting fortunes in their Europa League qualifying ties recently as Bohemians suffered penalty heartbreak against Hungarian side Fehérvár while Rovers beat Finnish club Ilves 12-11 in a mammoth penalty shootout.
Their reward is a clash with AC Milan at Tallaght Stadium on September 17th.
Meanwhile, Waterford host St Patrick's Athletic at 7.45pm tonight, Shelbourne host Cork City - currently rooted to the bottom of the table - at 5pm tomorrow and Sligo Rovers face Finn Harps on Monday evening.
League of Ireland fixtures