Ireland back-row Jack Conan has been ruled out of today's Six Nations clash against England due to illness.
Conan was due to be among the replacements, but will miss the game in Twickenham, with Connacht's Cian Prendergast coming into the squad.
Prendergast started the defeat to France in Paris in the opening game of the tournament, and will provide cover for the back row along with Nick Timoney.
Elsewhere, Ireland is set for no more late changes, with Jack Crowley starting at fly-half.
Tadhg Furlong, Jamison Gibson-Park, Tadhg Beirne, and Josh van der Flier all come into the starting line-up.
