Liverpool captain Steven Gerrard returned for the Champions League encounter against Lyon at Anfield but the surprise selection was teenage defender Martin Kelly.
The 19-year-old replaced England right-back Glen Johnson, who had a groin injury, for his maiden start and first appearance of the season.
Kelly’s previous first-team experience amounted to eight minutes as a substitute at PSV Eindhoven last December.
His inclusion and Gerrard’s return from a groin problem were among five changes from the side which lost at Sunderland on Saturday, with midfielder Javier Mascherano, striker David Ngog and Emiliano Insua also drafted in.
The French side, top of Ligue 1 and having won both their matches in the Champions League so far, fielded an experienced side which included the likes of Kim Kallstrom, Jeremy Toulalan, Lisandro Lopez and Sidney Govou.