The 35-year-old Welshman cracked the scaphoid bone in his left hand in the third, moments before referee Terry O’Connor stepped in to wave off the challenge of ’Contender’ reality TV star Manfredo.

And despite the fracture, Calzaghe remains hopeful of returning to the ring in July with a defence against Denis Inkin at the 02 Arena (formerly the Millennium Dome) a strong possibility – though American middleweight Jermain Taylor is the preferred option.

“I’m disappointed that I fractured my hand but that’s boxing and injuries happen,” he said.

“I shouldn’t be out for too long though, probably about four weeks, and then I’ll be back to light training in preparation for the proposed July date which I am really excited about.”

The win saw Calzaghe draw level with greats Larry Holmes and Bernard Hopkins for the consecutive number of world title defences, in front of a record crowd of more than 35,018.

Calzaghe added: “It was a fantastic occasion not just for me but for Enzo Maccarinelli, Gary Lockett, Bradley Pryce and the rest of the boys on the show.

“I was floored by the massive reception I got when I made my ring entrance and was very proud to be fighting at the national stadium in front of the biggest boxing crowd in over a decade.

“It is a moment that I will always remember throughout my career so it’s a big thank you to all my fans.”