Conor Murray and Paul O'Connell have both been omitted form the Munster squad for Saturday's RaboDirect PRO12 clash with Leinster at Thomond Park (7.30pm).
Both players have been out of action after picking up injuries during Ireland’s Six Nations campaign.
Murray was taken off against France after hyper-extending his leg while O’Connell damaged the medial collateral ligament in his left knee in the same game.
There had been optimism that Murray might make it back in time for this top of the table clash whereas O'Connell was always a doubt.
It's hoped however that both may be in contention for inclusion in the squad for the Heineken Cup clash against Ulster on Saturday week.
Meanwhile Munster have confirmed that Peter Stringer and Dave Foley have agreed one-year contract extensions.
Stringer is currently on loan to Newcastle Falcons while Foley who is out injured with a shoulder injury opted for a one-year contract instead of the offered two-year deal.
Munster Squad: Marcus Horan, Wian du Preez, BJ Botha, John Ryan, Stephen Archer, Damien Varley, Mike Sherry, Denis Fogarty, Donncha O’Callaghan, Mick O’Driscoll, Billy Holland, Dave O’Callaghan, Peter O’Mahony, Tommy O’Donnell, David Wallace, James Coughlan, Duncan Williams, Tomas O’Leary, Ronan O’Gara, Ian Keatley, Simon Zebo, Danny Barnes, Lifeimi Mafi, Keith Earls, Denis Hurley, Johne Murphy, Scott Deasy, Felix Jones,