German airline Lufthansa is to begin a daily summer service between Knock airport in Mayo and Dusseldorf from next May.
Connecting services to Berlin, Frankfurt, Hamburg and Munich will also be available as part of the new service.
Over 400,000 Germans visit Ireland each year.
The new services have the potential to bring in the region of 2,000 German tourists to the region generating a spend in excess of €1,000,000 for the West and North West regions, it has been claimed.
Transport Minister Leo Varadkar said the new route will benefit the whole region and has huge significance from a tourism point of view.
"Germany is a key market for Irish tourism as German tourists tend to stay for an average of a week at a time and travel more widely," Minister Varadkar said.
"This is a great example of how close co-operation between the transport and tourism sectors can deliver a successful result.”
Lufthansa are the world's fourth-largest airline, operating services to 203 international destinations in 78 countries across Africa, the Americas, Asia and Europe.