The county reported 497 new cases of Covid-19 during the period of September 23rd to midnight on October 6th.
The second highest county in terms of incidence rate is Monaghan at 257.4. It recorded a further 158 new cases of the virus during that period.
Dublin has the third highest incidence rate with 171.4, but it also had the highest amount of new cases with 2,309.
In terms of the breakdown within the county, Dublin North West accounted for the most new cases with 440, followed by Dublin North Central which accounted for 368 new cases.
Overall in this 14 day period, 5,925 cases of Covid-19 were reported, with the national incidence rate per 100,000 now standing at 124.43.
2,641 cases during this period were associated with hospitalisation, while 3,395 cases were from close contact with a confirmed cases.
1,471 cases were also associated with community transmission.
Both 15-24 year olds and 25-34 years old accounted for over 1,000 cases each, according to HPSC data. There were 1480 cases among 15- 24 years olds and 1044 cases among 24-34 year olds.
This comes as the HPSC recently reported 395 new clusters of Covid-19 in private households last week.
There were also 12 new clusters linked to schools, and 31 cases in meat plants - compared to only 15 the week before.
There are also currently five nursing homes across the country with 20 or more Covid-19 cases.
31 cases were reported in a nursing home in Laois recently, as well as nursing home in Donegal which reported 30 cases.
Concerns are being raised about the disease reentering these settings, after almost half of deaths linked to the disease happened in the facilities in the first wave.
According to the latest HPSC report there are currently 31 open clusters in nursing homes.