Striker Daryl Murphy has become the latest Republic casualty in joining injured quartet Shane Duffy, Ciaran Clark, Wes Hoolahan and Harry Arter, as well as the suspended Robbie Brady, on the sidelines.

Wales lost in-form Ipswich frontman Tom Lawrence to a hip injury on Monday, with his place taken by Liverpool youngster Harry Wilson.

But every member of Coleman's 23-man squad trained on Tuesday morning, including Liverpool's rising star Ben Woodburn.

The 17-year-old striker joined the likes of Gareth Bale and Aaron Ramsey at their Vale of Glamorgan base for the first time, and third-placed Wales appear in good health as they attempt to close the four-point gap on group leaders Ireland.

"We are a very good team when we're at our best and at our strongest," manager Coleman said.

"We need these players on the pitch consistently and we're in pretty good condition.

"The squad might have looked different two or three months ago.

"But we've got players back, and I've picked those who have been on the front foot and are most ready for this challenge."

Bale has already scored four times in this World Cup campaign to move within two of equalling Ian Rush's 28-goal Wales record.

The Real Madrid forward's recent comeback from ankle surgery is a huge boost for Wales, as is Arsenal midfielder Ramsey's return from a calf strain.

Ramsey was arguably Wales' best player in their march to the semi-finals of Euro 2016 last summer.

But his World Cup contribution so far has been minimal, with injury ruling him out of the opening three qualifiers.

"In these first four games we've only had Aaron in one of them," Coleman said.

"That's tough for us, and we've only had Joe Allen for two and a bit as well.

"We're looking forward to having Rambo back. He's had game time at Arsenal and he's feeling good."

This is Wales' first game since Coleman turned down overtures to take over his home town club Swansea at the turn of the year.