Radamel Falcao will lead the line for Manchester United against Arsenal today in what could be his last game at Old Trafford.
The Colombian striker, whose season-long loan from Monaco expires next month, comes in for the injured Wayne Rooney.
Robin van Persie has to settle for a place on the bench.
Marcos Rojo comes in for Luke Shaw in United's only other change.
Arsenal have named the same starting XI that lost to Swansea on Monday.
Man Utd: De Gea, Valencia, Smalling, Jones, Rojo, Blind, Mata, Ander Herrera, Fellaini, Young, Falcao.
Subs: Di Maria, Januzaj, van Persie, Valdes, McNair, Blackett, Wilson.
Arsenal: Ospina, Bellerin, Mertesacker, Koscielny, Monreal, Coquelin, Cazorla, Ramsey, Ozil, Sanchez, Giroud.
Subs: Szczesny, Gibbs, Gabriel, Rosicky, Wilshere, Walcott, Flamini.
Referee: Mike Dean