Coldplay, Kylie, Eminem, Pink, Shakira and Enrique Iglesias have been nominated for four MTV Europe Music awards each.
P Diddy will host the event in Barcelona on November 14, with live performances from Coldplay, Enrique Iglesias and Robbie Williams.
Kylie Minogue has been shortlisted for best female, best album, best dance and best pop.
Eminem is in the running for best male, best hip hop, best album and best video, while Coldplay are up for best group, best album, best rock and best UK and Ireland act.
Pink, Enrique Iglesias and Shakira are also quadruple nominees.
Speaking at the launch, P Diddy said: "We're going to have a big old party and there's not going to be a dull moment. It doesn't get any sexier than this - MTV, Barcelona and Diddy.
"So many times you see awards shows which leave you bored and unentertained. I want you to be able to feel the energy through your television sets.
"I've plans to make this the best one yet and we're going to try things that have never been done before. We're going to do it Diddy style."