Inspirational cancer charity fund-raiser Stephen Sutton, 19, died peacefully in his sleep this morning, his mother said on his Facebook page today.
"My heart is bursting with pride but breaking with pain for my courageous, selfless, inspirational son who passed away peacefully in his sleep in the early hours of this morning," his mother Jane wrote.
"The ongoing support and outpouring of love for Stephen will help greatly at this difficult time, in the same way as it helped Stephen throughout his journey.
"We all know he will never be forgotten, his spirit will live on, in all that he achieved and shared with so many."
Stephen had made headlines in recent weeks after he launched a campaign to raise money for the Teenage Cancer Trust and created a bucket-list of things to do before he died.
He raised more than £3.2m (€3.9m) for the charity.
Mr Sutton set up his charity fundraising website and blog on Facebook in January last year to keep people up to date with his progress.
His bucket-list included things like hugging an elephant, crowd-surfing in a rubber dinghy, playing the drums at a Wembley cup final, getting a tattoo and appearing on BBC drama Doctors.
Stephen, from Burntwood, Staffordshire, was readmitted to hospital on Sunday after developing breathing difficulties caused by the re-growth of tumours.