Finn Harps will be looking for an upset when they take on their north-west rivals Sligo Rovers at Finn Park, kick-off 8.00pm.
For Harps, Stephen McLaughlin misses out through suspension and Ciaran Gallagher remains sidelined.
Otherwise, manager James Gallagher has a full squad to choose from.
Gallagher said: “I havent had a chance to see them as often I would like, but I’ve received plenty of reports.
“As long as we can make them work hard for anything and leave everything out on the pitch, then you can’t argue too much with that.
“Sometimes your best might not be good enough. We’ve just got to make sure we give it our best shot.
“Obviously, it’s a cup tie and anything can happen. We just hope there can be a good crowd and a good atmosphere because the game deserves that.”
Sligo will be without six players for the cup clash with Harps as Joesph N'do, Romauld Boco, Gary McCabe, Conor O'Grady, Richard Brush and Mauro Almeida will all miss the tie.
N'do (leg) and Boco (Achillies) picked up injuries in the 0-0 draw with St Patrick's Athletic in Richmond Park last Friday.
McCabe has an ankle problem, while Brush and Almeida are long-term absentees.
O'Grady serves a one-game suspension for this first ever meeting of Sligo Rovers and Finn Harps in the FAI Cup.
In the last meeting the Bit o' Red were 4-1 winners in an EA Sports Cup match in May 2009.