Thomas Cook is to cut around 2,600 jobs across Europe and close a number of travel agencies.
The job cuts and closures come after the company reported a 12% fall in winter bookings.
There was no breakdown of how many jobs will go in the UK.
The company has already announced voluntary redundancy schemes and cuts in working hours following the US terror attacks.
Thomas Cook says the number of jobs across the group would be cut by 10%, planned capital expenditure would be reduced by 50%, and 100 travel agencies will be closed.
About 30,000 people are employed by Thomas Cook across Europe.
Alan Stewart, chief executive of Thomas Cook UK said: "It's very unfortunate that we are having to look at cost reduction measures across the group, but very necessary given the current trading conditions."