The Departed has landed three honours from the Southeastern Film Critics Association, including Best Picture and Best Director for Martin Scorcese.
The star-studded movie also picked up Best Adapted Screenplay for William Monahan in the 15th annual poll, voted for by 47 film critics in the nine US states making up the southeastern region of the country.
Elsewhere, Forest Whitaker was named Best Actor for his performance in The Last King Of Scotland, while Helen Mirren collected Best Actress for The Queen.
Al Gore's climate change documentary An Inconvenient Truth won Best Documentary.
Jackie Earl Haley was named Best Supporting Actor for Little Children, and Jennifer Hudson was named Best Supporting Actress for Dreamgirls.
Best Original Screenplay went to Little Miss Sunshine, and Cars picked up Best Animated Film.
Dixie Chicks documentary Shut Up And Sing won the Wyatt Award for the movie that best captures the spirit of the American south.