The Pentagon says US air strikes have killed senior leaders of the Taliban and al-Qaida.
A spokeswoman says the strikes have been targeting Taliban and al-Qaida command and control.
Victoria Clarke claims the strikes in Kabul and Kandahar killed senior members of both groups.
"There was some senior leadership. No evidence that it was Osama bin Laden," she added.
The spokeswoman says she has no numbers of those killed, nor identities to offer.
She says there will be no halt in the bombing over the Muslim holy month of Ramadan, which begins this weekend.
"The terrorists don't take a break, we don't take a break," she said.
The spokeswoman says she doesn't know how senior the leaders were.
The buildings were chosen as targets on the basis of intelligence information received prior to the strikes, she says.
Meanwhile, modest numbers of US special operations forces are in the south of Afghanistan, continuing such activities as roadblocks and searching out potential havens of opposition activity. Clarke declined to be more specific on the number.