Space shuttle Discovery has linked up with the International Space Station.
It is on a mission to provide fresh personnel and supplies.
NASA spokesman Rob Navias said everything was "in good shape on the station" and on Discovery.
The 12-day mission is carrying a team of seven astronauts to replace the three-member Alpha team stationed at the ISS since November.
The current mission marks the first phase of European collaboration, with the deployment of the Leonardo Multi-purpose Logistics Module.
The Leonardo "moving van" will shuttle equipment to and from the station for experiments to be performed in the US laboratory module Destiny or the future European laboratory Columbus.
Russian cosmonaut Yuri Usachov and US astronauts Susan Helms and James Voss will relieve US astronaut William Shepherd and Russians Yuri Gidzenko and Sergei Krikalyov.
Two space walks are planned on the mission, with the first scheduled for late Saturday or early Sunday.
Discovery is scheduled to return to Kennedy Space Centre on March 20.