The elevation of John Kelly and Rob Henderson to the Ireland senior squad means an international A debut for Connacht wing Ted Robinson who is named on the left wing.
It is fitting compensation for the Maynooth Co Kildare man who was named in the A squad for the game against Scotland but was then forced to withdraw because of a hamstring injury.
Besides the enforced changes in the backline there is one change up front with Jeremy Davidson coming into the second row, to partner Donncha O'Callaghan, in place of Mick O'Driscoll who drops to the bench.