“The thoughts of all staff at Cromwell Hospital are with Mr Best’s family at this time.”

Born in Belfast, Best played for United from 1963 to 1974 and his finest hour came in 1968 when the Red Devils became the first English club to win the European Cup.

Best made 180 goals in 474 appearances for United and also won two league championships, in 1965 and 1967.

A statement from United read: “George Best was one of the greatest footballers of all time.

“Naturally athletic, tough, confident and blessed with genius, his career was one of the brightest stars of its generation. His gifts were legendary.

“For the goals, the audacious dribbles and all the wonderful memories, Manchester United and its legions of fans worldwide will always be grateful.

“We feel a deep sense of loss but his spirit and his talent will live on forever.”

Bobby Charlton, a director at Old Trafford and a team-mate of Best’s during his time at the club, said: “Manchester United’s glorious history has been created by people like George Best.

“Anyone that witnessed what George could do on the pitch wished they could do the same. He made an immense contribution to the game, and enriched the lives of everyone that saw him play. It is a very sad day.

“Football has lost one of its greats, and I have lost a dear friend. He was a marvellous person and my thoughts are now with his family.”

The club will open a book of condolence tomorrow morning at Old Trafford.