Ante-post favourite Teofilo will miss Saturday’s Stan James 2000 Guineas at Newmarket after suffering a setback.
Last season’s champion two-year-old, trained in Ireland by Jim Bolger, was found to have some soreness at the back of his off-fore knee.
The Galileo colt won all his five starts as a two-year-old, including the Group One National Stakes and the Dewhurst Stakes at Newmarket.
He was 2-1 favourite to begin his pursuit of Triple Crown glory with victory in the 2000 Guineas.