The actions of gardaí on patrol duties in Tipperary resulted in the seizure of an estimated €550,000 worth of drugs and just over €20,000 in cash.
The gardaí became suspicious at the movement of a van in the Ballinure area and when they attempted to stop the vehicle, the driver kept driving.
After the officers gave chase two packages were seen being thrown out of the van into a field.
The garda patrol car subsequently stopped the van and arrested the male occupants, one of them aged 22 and another 45.
When the gardaí recovered the packages they were found to contain ecstasy tablets with an estimated street value of around €150,000.
Further inquiries were conducted resulting in a series of follow-up searches in Cashel and Killenaule.
This netted a haul of cannabis herb, worth in the region of €400,000, as well as cash totalling €21,000.
The incident happened on Monday afternoon.
Both men are currently detained at Thurles Garda Station under the provisions of Section 2 of the Criminal Justice (Drug Trafficking Act) 1996.
They can be held, on applications to the courts, for a maximum period of seven days.
Meanwhile, in a planned operation last Friday, gardaí in Carlow, assisted by the Garda Dog Unit, searched a premises at Phelim Wood in Tullow and recovered 6.5kg of cannabis herb.
Gardaí said the product had an estimated street value of €125,000.
A 44-year-old man was arrested at the scene and detained at Carlow Garda Station under Section 2 of the Drug Trafficking Act.
He can also be questioned for a maximum of seven days.