The 350th episode of The Simpsons will be screened in the US on Sunday, with the show's producers keen to continue the show.
"I don't see any end in sight," creator Matt Groening said, before adding that the animated hit would keep going as long as they could keep surprising viewers.
He said he was "particularly proud" of recent episodes.
Writers are already working on the next series, its 17th - a TV sitcom record. Also The Simpsons cast has signed for three more series.
In the 350th episode, Ray Romano from the sitcom Everybody Loves Raymond guest stars as the voice of Homer Simpson's new best friend.