Almost 400 jobs are to go following a decision by the multinational Xerox Corporation to close part of a plant in Co Louth.
The move affects inkjet production by Xerox in Dundalk, where the American company has a workforce of 1,000.
Staff will leave over the next six months, but the development is not expected to affect other Xerox operations in Dundalk or in other parts of Ireland, where there are a further 1,500 employees.
Earlier today more than 100 posts were lost through the closure of a toothpaste manufacturing plant in Dungarvan, Co Waterford, by GlaxoSmithKline.
The posts are to be transferred to Britain, where the company today announced hundreds of redundancies.
And yesterday, 120 jobs were axed when a weaving factory in Wexford went into liquidation.