The HSE says all babies born in Cork from this October onwards will be routinely offered the BCG vaccine against TB.
Their parents will also be offered advice on the matter prior to the baby's birth.
The move follows a recent outbreak of TB among children and staff members at two creches in Cork.
At the moment, the BCG jab is only administered to newborns who are at risk of developing TB, namely those whose parents or siblings have a history of the condition.
It is also given to children on request.