The Irish Nurses and Midwives Organisation says the cuts and new taxes announced in today's budget will have an effect on the Croke Park extension talks.
The organisations said the Budget will make any outcome on the extension to the Croke Park Agreement "very difficult and highly improbable".
They said the impact of today’s Budget will leave many members "simply unable to make ends meet and pay their way".
The INMO said: "Against this harsh reality, the idea that the Government, in January, will seek to impose further reductions on the earnings of public servants, just because they are public servants, is grossly unfair and simply unrealistic."
The INMO will consult with the other organisations in the 24/7 Frontline Alliance next Monday ahead of any discussions with Government in the coming weeks.
General Secretary Liam Doran said nurses cannot take anymore cuts.
He said: "There is an air of unreality within Government if it thinks that the vast majority of public servants, who are on ordinary incomes, have any more to give, or can suffer any further reductions in their income and still pay their bills and look after their families.
"The negative impact of all of the changes and charges, imposed by Government today, leaves the pending discussions extremely problematic and very unlikely to yield agreement, as our members have nothing more to give and we will protect them from any more cuts."