Amanda Knox said she will only be extradited to Italy "kicking and screaming", after judges reinstated her murder conviction for the death of British student Meredith Kercher.
Knox, who stayed in her native America for the trial, was sentenced to 28 years and six months and her former boyfriend Raffaele Sollecito jailed for 25 years.
It is not clear whether Knox, 26, will be expected to return to Italy to serve her jail term, but in a pre-recorded interview for BBC's 'Newsnight', she said: "I'm not willingly going back, no.
"It would feel like a train wreck. There's not a lot I can do after this appeal. They would order my arrest and the Italian government would approach the American government and say: 'Extradite her'.
"And I don't know what would happen. I'm still counting on an acquittal.
"I'll technically be considered a fugitive. I don't know what I will do though. I'm definitely not going back willingfully.
"They'll have to catch me and pull me back, kicking and screaming into a prison I don't deserve to be in."
Speaking after the case, Knox issued a statement in which she was "frightened and saddened" and was going to appeal against the decision.
Knox described the ruling as "inconsistent and unfounded" and her co-accused was said to have been "astonished" with the way the court kept changing its mind.
Neither defendant was in the courtroom as the verdict was announced, though Sollecito, 29, had attended the lengthy hearings.
Members of 21-year-old Miss Kercher's family were there to hear the verdict - and said they would not be able to forgive those responsible for her death.
Miss Kercher, a Leeds University exchange student from Coulsdon, Surrey, was found with her throat slashed