Captain Wayne Rooney starts in central midfield in an injury-depleted Manchester United side at Premier League leaders Chelsea.
With Phil Jones (ankle), Marcos Rojo (adductor), Jonny Evans (suspended), Michael Carrick (calf) and Daley Blind (ankle) out, Louis van Gaal is forced to make three changes following the derby defeat of Manchester City.
Paddy McNair, Luke Shaw and Radamel Falcao start with Robin van Persie among the substitutes.
Chelsea, bidding for a victory to go 10 points clear of second-placed Arsenal, make two changes following the win at QPR, with Kurt Zouma drafted into midfield in place of Ramires and Oscar in for Willian.
Chelsea: Courtois, Ivanovic, Terry, Cahill, Azpilicueta, Zouma, Matic, Oscar, Fabregas, Hazard, Drogba.
Subs: Cech, Luis, Ramires, Mikel, Willian, Cuadrado, Solanke.
Man Utd: De Gea, Valencia, Smalling, McNair, Shaw, Rooney, Mata, Ander Herrera, Fellaini, Young, Falcao.
Subs: Da Silva, Di Maria, Januzaj, van Persie, Valdes, Blackett, Pereira.
Referee: Mike Dean (Wirral)