Liverpool goalkeeper Simon Mignolet paid the price for his poor form as Brendan Rodgers rang the changes for their grudge match at Manchester United.
Back-up stopper Brad Jones will make his first Premier League appearance since March 2013, with Rodgers also drafting in Philippe Coutinho, Alberto Moreno, and Adam Lallana.
Rickie Lambert and Mario Balotelli are named on the substitutes’ bench, which means Raheem Sterling is likely to start up front.
United teenager James Wilson starts ahead of Radamel Falcao while Phil Jones returns in central defence after a two-month absence.
Man Utd: De Gea, Valencia, Jones, Evans, Young, Carrick, Fellaini, Mata, Rooney, van Persie, Wilson.
Subs: Falcao, Januzaj, Lindegaard, Ander Herrera, Fletcher, McNair, Blackett.
Liverpool: Brad Jones, Johnson, Skrtel, Lovren, Moreno, Henderson, Gerrard, Allen, Coutinho, Sterling, Lallana.
Subs: Toure, Lambert, Lucas, Mignolet, Can, Balotelli, Markovic.
Referee: Martin Atkinson.