Jonny Evans again misses out as Manchester United visit Tottenham on Sunday.
Manager Alex Ferguson had hoped the Northern Ireland international would have shrugged off a slight hamstring strain but Evans was unable to train this morning and has been ruled out.
Plenty of changes are anticipated following the midweek FA Cup win over West Ham, with Robin van Persie amongst those set to return.
Team (from): Lindegaard, De Gea, Amos, Smalling, Vidic, Ferdinand Evans, Buttner, Evra, Cleverley, Giggs, Fletcher, Anderson, Scholes, Carrick, Kagawa, Nani, Hernandez, Rooney, Welbeck, Van Persie.