Sene Naoupu, Alison Miller and Hannah Tyrrell will miss Ireland's Women's Six Nations match against France at Donnybrook on Sunday.
They've instead been called up for the Ireland Sevens squad for the Las Vegas 7s.
Claire McLaughlin, Sophie Spence, Mairead Coyne, Mary Healy, Eimear Considine and Kim Flood come into a new look side.
Commenting on the selection, Tom Tierney said:
"We've got a couple of players getting their first Six Nations starts of this season, and we're looking to continue to give players more game-time as we continue to develop depth in the squad ahead of the Women's Rugby World Cup in August.
"It's our first home game of the Six Nations so we're hoping to see a big turnout of fans on Sunday in Donnybrook."
Here's the Ireland Women's team to face France this Sunday in Donnybrook. Tickets available on ticketmaster.ie #BRINGIT #WomensSixNations pic.twitter.com/YW8HzKz9TN
— Irish Rugby (@IrishRugby) February 23, 2017
15. Mairead Coyne
14. Kim Flood
13. Jenny Murphy
12. Claire Mc Laughlin
11. Eimear Considine
10. Nora Stapleton
9. Mary Healy
1. Lindsay Peat
2. Leah Lyons
3. Ailis Egan
4. Sophie Spence
5. Marie-Louise Reilly
6. Ciara Griffin
7. Claire Molloy
8. Paula Fitzpatrick (captain)
16. Ciara O Connor
17. Ilse Van Staden
18. Ruth O’Reilly
19. Ciara Cooney
20. Nichola Fryday
21. Larissa Muldoon
22. Nikki Caughey
23. Louise Galvin