Robbie Henshaw will make his 50th appearance for Connacht when he starts for them against Glasgow Warriors on Friday night.
Connacht have had a dream start to the PRO12 season with three wins including an epic victory over neighbours Leinster last weekend.
Coach Pat Lam has made a total of five changes to the starting 15 from that game.
Michael Swift makes his first appearance of the season, replacing Quinn Roux in the second row.
Tighthead prop Rodney Ah You and number eight George Naoupu both earn their first starts of the season, having made previous appearances from the bench.
Eoin McKeon, who is also making his 50th appearance, moves to openside flanker this week to be replaced on the right wing by Daniel Poolman while Matt Healy moves to the left.
26-year-old new recruit Ian Porter has been named at scrum half.
: Darragh Leader, Danie Poolman, Robbie Henshaw, Dave McSharry, Matt Healy, Jack Carty, Ian Porter, Denis Buckley, Dave Heffernan, Rodney Ah You, Michael Swift, Aly Muldowney, John Muldoon - capt, Eoin McKeon, George Naoupu.
: Shane Delahunt, Ronan Loughney, Nathan White, Quinn Roux, Mick Kearney, John Cooney, Craig Ronaldson, Fionn Carr.
:Stuart Hogg, Sean Lamont, Mark Bennett, James Downey, DTH van der Merwe, Duncan Weir, Henry Pyrgos, Gordon Reid, Pat MacArthur, Euan Murray, Tim Swinson, Al Kellock - capt, Rob Harley, Chris Fusaro, Adam Ashe.
: Kevin Bryce, Jerry Yanuyanutawa,. Rossouw de Klerk, Tom Ryder, James Eddie, Murray McConnell, Finn Russell, Tommy Seymour.
The match kicks-off at 7.35pm on Friday September 26 at Scotstoun Stadium.