At least 100 jobs are expected to be announced at the Mater Private Hospital in Mahon, Cork today.
More than 190 full and temporary positions are being created in Dublin, Cork, Donegal and Meath in four separate job announcements today.
More than 80 new jobs are set to come on stream at security firm Homesecure.
Up to 100 jobs are to be created with the expansion of three companies in Dublin, Cork and Laois.
Sixty new jobs have been created at a new 24-hour McDonald's restaurant on Dublin's southside.