160 jobs are to go at a Dublin-based pharmaceutical company.
Bristol-Myers Squibb is closing its manufacturing facility in Cruiserath by the end of next year resulting in 130 lay offs, while 30 jobs will go at a unit at the firm's plant in Swords.
Staff were told the news in a series of meetings today at the American pharmaceutical company.
They are blaming a change in market demand for products it makes at one of its plants.
Bristol-Myers Squibb has been making pharmaceuticals in Ireland for 50 years, and currently employs 550 people.
This afternoon, 130 workers at its Cruiserath manufacturing plant in Dublin 15 were told that the plant will close, with the loss of all jobs, by the end of next year.
In a statement, BMS says the closure reflects changing market demand, and a spokesperson said it was not as a result of drugs coming off patent.
BMS says it remains committed to its Swords facility, which employs 320 staff - but a unit there will also close by the end of 2015 - with the loss of 30 positions.
They said the Swords plant remains a "key supplier" of bulk pharmaceuticals.
In a statement, the company said it is working with IDA Ireland to explore potential future uses of the Cruiserath facility and will endeavour to minimize job losses in Ireland.