Protesters are due to picket the arrival of the European Trade Commissioner in Dublin this morning.
Commissioner Cecilia Malmstrom is visiting to discuss the Transatlantic Trade and Investment Partnership.
The agreement is being negotiated between the EU and the US with the aim of making it easier for companies on both sides of the Atlantic to access each other's markets.
Concerns have been expressed about how the agreement could affect small businesses here.
Chairman of the EU Affairs Committee Dominic Hannigan, said people's concerns would be put to the Commissioner during the meeting.
"I have no doubt there will be robust questions put to her in relation to the negotiations," he said. "People have concerns relating to employment rights and the impact on small businesses."