Finance Minister Michael Noonan is expected to offer reassurances about the country's enduring appeal when he meets potential investors in the United States this week.
The visit was planned following the outcome of the UK referendum on Brexit, which Mr Noonan said presented an important challenge for the Irish economy.
As well as representatives from large US companies which have bases in Ireland, the minister will also meet US Treasury Secretary Jack Lew and officials from the IMF and World Bank.
Mr Noonan said: "Ireland has strong ties with the US and this is most evident in terms of inward investment from American companies.
"I meet regularly with current and prospective investors from the US and this visit will allow me to emphasise Ireland's attractiveness as a destination for foreign direct investment following the UK's decision to exit the European Union.
"Companies invest in Ireland for a broad range of reasons, not least to access the world's largest economic bloc, the European Union.
"As a common law, English speaking and business friendly jurisdiction we will continue to be an attractive destination for US companies.
"We will continue to look outwardly and engage with investors with a view to encouraging substantive investment in Ireland which creates high-quality employment for our people."
Last month Foreign Minister Charlie Flanagan expressed concern after Stormont First Minister Arlene Foster accused Dublin officials of poaching foreign investment and of talking down the Northern Ireland economy.